Biotie Therapies - Company Announcement

Biotie Advances Clinical Program for SYN120 with Imaging Study at Johns Hopkins Center of Excellence

BIOTIE THERAPIES CORP.      STOCK EXCHANGE RELEASE       25 July 2011, at 9.00
a.m.

Biotie Advances Clinical Program for SYN120 with Imaging Study at Johns Hopkins
Center of Excellence

Biotie today announced the start of a Phase 1 clinical study using positron
emission tomography (PET) imaging to investigate brain concentrations of SYN120,
a potential treatment for cognitive disorders including Alzheimer's disease and
schizophrenia.

The trial of healthy volunteers is being conducted by Dr Dean Wong at the Johns
Hopkins University School of Medicine in the United States to determine
occupancy of the 5-HT6 receptor in the brain following different doses of
SYN120. This will help to establish the appropriate dose for subsequent Phase 2
trials."This is an important step in our development program for SYN120, which we
believe is a potential best-in-class compound targeting the 5HT6 receptor with
significant potential to help patients suffering from Alzheimer's disease and
other diseases affecting cognition," commented Dr Stephen Bandak, Biotie's Chief
Medical Officer. "We are particularly pleased to collaborate with the leading
PET center for this type of research in the United States."

Results from the study are expected in the first half of 2012.

About SYN120

SYN120 is a potent, selective and orally bioavailable 5HT6 receptor antagonist,
exclusively targeting regions in the brain associated with memory function.
SYN120 has been shown to enhance cognition in various preclinical models.

The compound was discovered at Roche and is being developed by Biotie under a
licensing agreement. SYN120 has completed single and multiple-ascending dose
studies in Phase 1. Roche retains an opt-in right on the 5HT6 program on
completion of the imaging study.

Turku, 25 July 2011

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Media contact:
Julie Walters, Tudor Reilly
Office: +44 (0) 20 7034 7610
Mobile +44 (0) 775 362 6967

Virve Nurmi, Investor Relations Manager
tel. +358 2 274 8911, e-mail: virve.nurmi@biotie.com

www.biotie.com

Distribution:
NASDAQ OMX Helsinki Ltd
Main Media

About Biotie Therapies

Biotie is a specialized drug development company focused on the development of
drugs for neurodegenerative and psychiatric disorders (Parkinson's disease,
Alzheimer's disease and other cognitive disorders, bipolar disorder, and alcohol
and drug dependence) and inflammatory diseases (rheumatoid arthritis, psoriasis,
chronic obstructive pulmonary disease and others). It has several innovative
small molecule and biological drug candidates at different stages of clinical
development. Biotie's products address diseases with high unmet medical need and
significant market potential.

Partnerships with top-tier pharmaceutical partners are in place for several
programs as well as a strategic collaboration with UCB Pharma S.A. Biotie's most
advanced product, nalmefene for alcohol dependence, has completed Phase 3
clinical development by licensing partner H. Lundbeck A/S.

Biotie shares are listed on NASDAQ OMX Helsinki Ltd.




[HUG#1533079]