Biotie Therapies - Major shareholder announcements

Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act

BIOTIE THERAPIES CORP.    STOCK EXCHANGE RELEASE January 3, 2011 at 4.30 p.m.

Notification according to Chapter 2, Section 10 of the Finnish Securities Market
Act

Biotie Therapies Corp. ("Company") has gained knowledge of the notifications
regarding the following changes in holdings in accordance with Chapter 2,
Section 9 of the Finnish Securities Markets Act.

Pequot Capital Management, Inc (SEC-registration number 801-56015) address 187
Danbury Road, Wilton, CT 06897, United States of America ('Pequot') has notified
Company that as a result of share transactions carried out on 29 December, 2010
certain changes in holdings of the Company's shares have taken place that are
under Pequot's management.

As a result of these share transactions, the aggregate holdings of the below
funds have decreased from above 5 % of the number of shares of the Company.

The changes in holdings in accordance with Chapter 2, Section 9 of the Finnish
Securities Markets Act of which the Company has gained knowledge are described
below:

Name of the          Shares prior to the    Shares after the   % of shares after
shareholder                 transactions        transactions    the transactions

Pequot Diversified               751,000             516,000               0.29%
Liquidating Trust;
Wilmington Trust
Company, Rodney
Square North, 1100
North Market Street,
Wilmington, DE
19890, United States
of America;


Pequot HC                      4,688,170           3,220,141               1.83%
Liquidating Trust;
Wilmington Trust
Company, Rodney
Square North, 1100
North Market Street,
Wilmington, DE
19890, United States
of America;


Pequot HC EM                   2,040,770           1,402,170               0.80%
Liquidating Trust;
Wilmington Trust
Company, Rodney
Square North, 1100
North Market Street,
Wilmington, DE
19890, United States
of America;


Pequot HC                      1,288,406             885,206               0.50%
Institutional
Liquidating Trust;
Wilmington Trust
Company, Rodney
Square North, 1100
North Market Street,
Wilmington, DE
19890, United States
of America; and


Pequot HC Offshore             3,686,577           2,532,677               1.44%
Liquidating Trust
Wilmington Trust
Company, Rodney
Square North, 1100
North Market Street,
Wilmington, DE
19890, United States
of America.


Total                         12,454,923           8,556,194               4.86%




The registered number of shares in Biotie Therapies Corp. is 176.003.931. Of
these shares 14.747.084 are held by the Company and the number of outstanding
shares and voting rights attached to the shares amounts thus to 161,256,847. The
voting rights attached to the Company's shares held by Pequot still exceeds
1/20 as the number of votes attached to shares held by Pequot amounts to 5.31 %
of the total number of votes in the Company.

Turku, January 3, 2011

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Biotie Therapies Corp.
tel. +358 2 274 8900
e-mail:virve.nurmi@biotie.com

DISTRIBUTION
NASDAQ OMX Helsinki Ltd
Main Media
www.biotie.com


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