Biotie Therapies - Major shareholder announcements

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       February
12, 2016 at 1:15 p.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the
"Company") has on February 11, 2016 received a notification in accordance with
Chapter 9, Section 5 of the Finnish Securities Markets Act, according to which
the holding of FMR LLC and its controlled entity FMR CO., Inc in Biotie's shares
has fallen below the threshold of 5 per cent on February 10, 2016.

According to the notification, the holding of FMR LLC and its controlled entity
FMR CO., Inc in Biotie's shares has decreased to 51,081,360 shares,
corresponding to 4.69 per cent of Biotie's shares and voting rights. The total
number of Biotie shares owned directly or through financial instruments by FMR
LLC and its controlled entity FMR CO., Inc was 6.25 per cent of Biotie's total
number of shares and voting rights on February 10, 2016. Biotie's registered
total number of shares and voting rights amounting to 1,089,608,083 has been
used in the calculation of percentages for the announcement.

Total positions of FMR LLC and its controlled entity FMR CO., Inc subject to the
notification:

+-----------------------+----------------+---------------------+---------------+
|                       |% of shares and |% of shares and      |Total of both  |
|                       |voting rights   |voting rights through|in % (A + B)   |
|                       |(total of A)    |financial instruments|               |
|                       |                |(total of B)         |               |
+-----------------------+----------------+---------------------+---------------+
|Resulting situation on |4.69            |1.56                 |6.25           |
|the date on which      |                |                     |               |
|threshold was crossed  |                |                     |               |
|or reached             |                |                     |               |
+-----------------------+----------------+---------------------+---------------+
|Position of previous   |6.73            |N/A                  |6.73           |
|notification (if       |                |                     |               |
|applicable)            |                |                     |               |
+-----------------------+----------------+---------------------+---------------+

Notified details of the resulting situation on the date on which the threshold
was crossed or reached:

A: Shares and voting rights

+----------------------+----------------------------+--------------------------+
|Class/type of shares  |Number of shares and voting |% of shares and voting    |
|ISIN code (if         |rights                      |rights                    |
|possible)             +---------+------------------+---------+----------------+
|                      |Direct   |Indirect          |Direct   |Indirect        |
|                      |(SMA 9:5)|(SMA 9:6 and 9:7) |(SMA 9:5)|(SMA 9:6 and    |
|                      |         |                  |         |9:7)            |
+----------------------+---------+------------------+---------+----------------+
|Shares                |-        |51,081,360        |-        |4.69            |
|(FI0009011571)        |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|                      |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|SUBTOTAL A            |51,081,360                  |4.69                      |
+----------------------+----------------------------+--------------------------+



B: Financial instruments according to SMA 9:6a

+-------------+-------------+-------------+-------------+-------------+--------+
|Type of      |Expiration   |Exercise/    |Physical or  |Number of    |% of    |
|financial    |date         |Conversion   |cash         |shares and   |shares  |
|instrument   |             |period       |settlement   |voting rights|and     |
|             |             |             |             |             |voting  |
|             |             |             |             |             |rights  |
+-------------+-------------+-------------+-------------+-------------+--------+
|Right of     |N/A          |N/A          |Physical     |16,976,000   |1.56    |
|Recall       |             |             |settlement   |             |        |
+-------------+-------------+-------------+-------------+-------------+--------+
|             |             |             |             |             |        |
+-------------+-------------+-------------+-------------+-------------+--------+
                                          |SUBTOTAL B   |16,976,000   |1.56    |
                                          +-------------+-------------+--------+

Full chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held starting with the ultimate
controlling natural person or legal entity:

+----------------------+------------------+----------------------+-------------+
|Name                  |% of shares and   |% of shares and voting|Total of both|
|                      |voting rights     |rights through        |             |
|                      |                  |financial instruments |             |
+----------------------+------------------+----------------------+-------------+
|FMR LLC               |0                 |0                     |0            |
+----------------------+------------------+----------------------+-------------+
|Fidelity Management & |0                 |0                     |0            |
|Research Company      |                  |                      |             |
+----------------------+------------------+----------------------+-------------+
|FMR CO., Inc          |4.69%             |1.56%                 |6.25%        |
+----------------------+------------------+----------------------+-------------+



In Turku, February 12, 2016

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Investor Relations Manager, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

DISTRIBUTION:

Nasdaq Helsinki Ltd
Main Media
www.biotie.com






[HUG#1985853]