Biotie Therapies - Major shareholder announcements

Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act

BIOTIE THERAPIES CORP.    STOCK EXCHANGE RELEASE 3 February 2011 at 5.30 p.m.

Notification according to Chapter 2, Section 10 of the Finnish Securities Market
Act

Biotie Therapies Corp. ("Company" or "Biotie") has gained knowledge of the
notifications regarding changes in holdings in accordance with Chapter 2,
Section 9 of the Finnish Securities Markets Act, described below.

The notifications received by the Company concern the changes in holdings of
Suomen itsenäisyyden juhlarahasto ("Sitra").

The mentioned change in holdings is related to the Combination Agreement entered
into on 10 January 2011 among the Company, Synosia Therapeutics Holding AG
("Synosia") as well as Synosia's shareholders and warrant holders, described in
more detail in a stock exchange release issued on 11 January 2011. As described
in detail in Biotie's stock exchange release issued on 2 February 2011, Biotie's
Extraordinary General Meeting has on 1 February 2011 passed resolutions
necessary for the completion of the transaction and the other prerequisites for
the completion of the transaction have been fulfilled, and the Company has
issued 161,448,371 shares to the shareholders and warrant holders of Synosia as
consideration for the entire issued share capital and outstanding warrants of
Synosia (the "Transaction"). In connection with the Transaction, the Company
issued 14,912,155 new shares to Synosia to be held in treasury and used to
satisfy future potential exercise of Synosia's options. The new shares have been
registered on 3 February 2011.

As a consequence of the Transaction Sitra's holding of shares and votes in the
Company decreased below 5 % as follows:

Name            Number of    Number of    Number of    Share of     Share of
                shares       voting       shares and   share        voting
                before       rights       voting       capital      rights after
                Transaction  before       rights after after        Transaction
                             Transaction  Transaction  Transaction  (%)
                                                       (%)

Suomen          13,585,350   13,585,350    13,585,350  3.86         4.21
itsenäisyyden
juhlarahasto



The number of voting rights and percentages presented above are calculated based
on number of shares and voting rights obtained upon completion of the
Transaction taking into account the treasury shares held by the Company on the
date of the notification.

On the date hereof, the registered number of shares in Biotie Therapies Corp. is
352,364,457. Of these shares 29,659,239 are held by the Company or its group
companies and the number of outstanding registered shares and voting rights
attached to such shares amounts thus to 322,705,218.

Turku, 3 February 2011

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Biotie Therapies Corp.
tel. +358 2 274 8900
e-mail:virve.nurmi@biotie.com

DISTRIBUTION
NASDAQ OMX Helsinki Ltd
Main Media
www.biotie.com


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