Biotie Therapies - Major shareholder announcements

Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act

BIOTIE THERAPIES CORP.    STOCK EXCHANGE RELEASE 22 March 2011 at 3.45 p.m.

Notification according to Chapter 2, Section 10 of the Finnish Securities Market
Act

Biotie Therapies Corp. ("Company" or "Biotie") has gained knowledge of a
notification regarding changes in holdings in accordance with Chapter 2, Section
9 of the Finnish Securities Markets Act, described below.

The notification received by the Company concerns the changes in holdings of
Invesco Limited (through Invesco Fund Managers Limited)

The mentioned change in holdings is related to the private placement of shares
(the "Offering") described in more detail in a stock exchange release issued on
11.3.2011. In the Offering a total of 35,230,000 newly issued and 14,747,084
treasury shares were offered to Finnish and international institutional and
strategic investors. As a result of the Offering and the registration of the
offered new shares with the Finnish Trade Register on 18 March 2011, the
resulting holdings of shares and votes in the Company of Invesco Limited
(through Invesco Fund Managers Limited) is as follows:

Name         Number of      Number of      Number of     Share of    Share of
             shares before  voting rights  shares and    share       voting
             the Offering   before the     voting rights capital     rights
                            Offering       after the     after the   after the         Offering      Offering    Offering
                                                         (%)         (%)

Invesco      14,432,000     14,432,000     44,273,256    11.42 %     11.88 %
Limited
(through
Invesco Fund
Managers
Limited)

Total        14,432,000     14,432,000     44,273,256    11.42 %     11.88 %




The number of voting rights and percentages presented above are calculated
taking into account the treasury shares held by the Company or its group
companies at the date of this release.

As a result of the Offering and the registration of the new shares offered, the
share of voting rights, calculated taking into account the treasury shares held
by the Company or its group companies, of both 5AM Partners LLC (through 5AM
Ventures LLC and 5AM Co-Investors LLC) and Abingworth Management Limited
(through Abingworth Bioventures IV LP and Abingworth Bioventures IV Executives
LP) have, according to the Company's knowledge, fallen below 5 %. The share of
the share capital of both above mentioned shareholders remains below 5 %.

On the date hereof, the registered number of shares in Biotie is 387,594,457. Of
these shares, 14,912,155 are held by the Company or its group companies.



Turku, 22 March 2011

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Biotie Therapies Corp.
tel. +358 2 274 8900
e-mail:virve.nurmi@biotie.com

DISTRIBUTION
NASDAQ OMX Helsinki Ltd
Main Media
www.biotie.com


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