Biotie Therapies - Major shareholder announcements

Notification according to Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       June 17, 2015 at
6.30 p.m.

Notification according to Chapter 9, Section 5 of the Finnish Securities Markets
Act

Biotie Therapies Corp. (the "Company" or "Biotie") has received a notification
in accordance with Chapter 9, Section 5 of the Finnish Securities Markets Act
from Mr. Samuel D. Isaly on behalf of himself, OrbiMed Advisors LLC, OrbiMed
Capital GP V LLC and OrbiMed Private Investments V, LP (the "Investor")
concerning changes in share ownership and an arrangement which, if realized,
would result in changes in share ownership.

The Company previously announced on April 24, 2015 that it had received a
notification regarding possible changes in holdings from Mr. Samuel D. Isaly on
behalf of himself and the above mentioned entities. According to the previous
notification, should the convertible promissory notes (the "Convertible Notes")
and other equity-based instruments (the "Warrants") pursuant to the subscription
agreement entered into between Biotie and certain investors be issued to the
Investor, their conversion and exercise in full would have resulted in a
combined holding of shares and votes that would exceed 10 per cent.

According to the notification received today by the Company, Samuel D. Isaly is
the managing member of and owner of a controlling interest in OrbiMed Advisors
LLC, which is the sole managing member of OrbiMed Capital GP V LLC, which is the
general partner of OrbiMed Private Investments V, LP. According to the
notification, neither Samuel D. Isaly nor any other entity under his control,
other than OrbiMed Private Investments V, LP, holds any shares or securities
entitling to shares in the Company.

According to the notification, the current shareholding by the Investor through
ordinary shares and American Depositary Shares ("ADSs") in the Company is as
described below:

+-------------------------+-------------------------+--------------------------+
|                         |Number of shares and     |(%) of shares and voting  |
|                         |voting rights            |rights (calculated by the |
|                         |                         |Company based on the      |
|                         |                         |current number of shares) |
+-------------------------+-------------------------+--------------------------+
|Shares and voting rights |73,438,204               |7.49                      |
|currently held           |                         |                          |
+-------------------------+-------------------------+--------------------------+


The notification further refers to the Warrants, which are described in more
detail in the stock exchange release issued by the Company on April 23, 2015.
The subscription of shares based on the Warrants is conditional, among other
things, on the Warrant holder's decision to subscribe for shares and the
occurrence of certain events. To this extent, the notification concerns an
arrangement that, if realized, would result in the below described changes in
share ownership.

According to the notification, the exercise in full of the Warrants would result
in shareholding by the Investor in the Company as described below:

+---------------------------+---------------------------+----------------------+
|                           |Number of shares and voting|(%) of shares and     |
|                           |rights                     |voting rights         |
+---------------------------+---------------------------+----------------------+
|Shares and voting rights   |73,438,204                 |6.31                  |
|currently held             |                           |                      |
+---------------------------+---------------------------+----------------------+
|Shares that may be         |51,944,444                 |4.46                  |
|subscribed based on        |                           |                      |
|Warrants                   |                           |                      |
+---------------------------+---------------------------+----------------------+
|TOTAL                      |125,382,648                |10.77                 |
+---------------------------+---------------------------+----------------------+


According to the notification, the total number of shares and votes used above
is 1,164,185,269, which has been calculated as (a) the current total number of
shares and votes as published by the Company in accordance with Chapter 8,
Section 6 of the Securities Markets Act (980,851,935 shares and votes), added
with (b) the total number of shares and votes following full conversion of the
Warrants (183,333,334 shares and votes), assuming no other new shares are issued
by the Company.

On the date of this release, the number of shares in Biotie Therapies Corp.
amounts to 980,851,935, of which 2,605,691 shares are held by the Company and
its subsidiaries.



In Turku, June 17, 2015

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

David Cook, CFO
Tel. +358 2 2748 900, e-mail: david.cook@biotie.com

DISTRIBUTION:

NASDAQ OMX Helsinki Ltd
Main Media
www.biotie.com






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