Biotie Therapies - Major shareholder announcements

Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act

BIOTIE THERAPIES CORP.    STOCK EXCHANGE RELEASE 4 February 2011 at 11.45

Notification according to Chapter 2, Section 10 of the Finnish Securities Market
Act

Biotie Therapies Corp. ("Company" or "Biotie") has gained knowledge of the
notifications regarding changes in holdings in accordance with Chapter 2,
Section 9 of the Finnish Securities Markets Act, described below.

The notifications received by the Company concern the changes in holdings of
Invesco Limited (through Invesco Fund Managers Limited) ("Invesco").

The mentioned change in holdings is related to the Combination Agreement entered
into on 10 January 2011 among the Company, Synosia Therapeutics Holding AG
("Synosia") as well as Synosia's shareholders and warrant holders, described in
more detail in a stock exchange release issued on 11 January 2011. As described
in detail in Biotie's stock exchange release issued on 2 February 2011, Biotie's
Extraordinary General Meeting has on 1 February 2011 passed resolutions
necessary for the completion of the transaction and the other prerequisites for
the completion of the transaction have been fulfilled, and the Company has
issued 161,448,371 shares to the shareholders and warrant holders of Synosia as
consideration for the entire issued share capital and outstanding warrants of
Synosia (the "Transaction"). In connection with the Transaction, the Company
issued 14,912,155 new shares to Synosia to be held in treasury and used to
satisfy future potential exercise of Synosia's options. The new shares have been
registered on 3 February 2011.

As a consequence of the Transaction Invesco's holding of shares and votes in the
Company decreased below 5 % as follows:

Name       Number of     Number of     Number of     Share of      Share of
           shares before voting rights shares and    share capital voting rights
           Transaction   before        voting rights after         after
                         Transaction   after         Transaction   Transaction
                                       Transaction   (%)           (%)

Invesco    14,432,000    14,432,000     14,432,000   4,10          4,10
Limited
(through
Invesco
Fund
Managers
Limited)



On the date hereof, the registered number of shares in Biotie Therapies Corp. is
352,364,457. Of these shares 29,659,239 are held by the Company or its group
companies.

Turku, 4 February 2011

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Biotie Therapies Corp.
tel. +358 2 274 8900
e-mail:virve.nurmi@biotie.com

DISTRIBUTION
NASDAQ OMX Helsinki Ltd
Main Media
www.biotie.com


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