Biotie Therapies - Major shareholder announcements

Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act relating to decrease in holdings

BIOTIE THERAPIES CORP. STOCK EXCHANGE RELEASE January 13, 2010, at 10 a.m.


Notification according to Chapter 2, Section 10 of the Finnish Securities Market
Act relating to decrease in holdings

Biotie Therapies Corp. ("Company") has gained knowledge of the notification
regarding the following changes in holdings in accordance with Chapter 2,
Section 9 of the Finnish Securities Markets Act. The change (decrease below
1/10 of total number of shares) in holdings relate to the increase in the total
number of shares in the Company as a result of the directed share offering
registered on 14 December 2009.

TVM Life Science Ventures VI GmbH & Co. KG has notified that as a result of the
Company issuing 14,432,000 new shares in the directed offering as registered on
December 14, 2009, their holdings has decreased below 1/10 to 9.64% of total
number of shares and votes in the Company.

The holdings in accordance with Chapter 2, Section 9 of the Finnish Securities
Markets Act of which the Company has gained knowledge is described below.


 Name of the shareholder                 Shares  % of shares after the issuance
                                                                  of new shares


 TVM Life Science Ventures VI GmbH & 15,302,500                           9.64%
 Co. KG



The registered number of shares in Biotie Therapies Corp. is 158,752,560 and the
number of voting rights attached to the shares amounts to 158,289,305.

In Turku, 13 January 2010

Biotie Therapies Corp.
Timo Veromaa, President and CEO

For further information, please contact:
Virve Nurmi, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com<mailto:virve.nurmi@biotie.com>

www.biotie.com

DISTRIBUTION:

NASDAQ OMX Helsinki Ltd
Main Media


DISTRIBUTION
NASDAQ OMX Helsinki Ltd
Main Media



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