Biotie Therapies - Major shareholder announcements

Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act

BIOTIE THERAPIES CORP.   STOCK EXCHANGE RELEASE 10 DECEMBER 2009 at
12.15


Notification according to Chapter 2, Section 10 of the Finnish
Securities Market Act

Biotie Therapies Corp. ("Biotie" or the "Company") has on 10 December
2009 gained knowledge of the notification regarding the following
change in holdings in accordance with Chapter 2, Section 9 of the
Finnish Securities Markets Act.

Finnish Innovation Fund (Sitra) has notified the Company that as a
result of a share transaction carried out on 7 December 2009, the
holdings of Finnish Innovation Fund (Sitra) in the Company have
decreased below 1/10 (i.e. 10 %), however, the holdings still exceed
1/20 (i.e. 5 %) of the total number of shares and votes in Biotie.

The change in holdings in accordance with Chapter 2, Section 9 of the
Finnish Securities Markets Act is described below.



+---------------------------------------------------------------------+
|Name of the  |Shares after|Holdings  |Holdings  |Holdings  |Holdings |
|share-       |the trans-  |of shares |of shares |of votes  |of votes |
|holder       |action      |before the|after the |before the|after the|
|             |            |trans-    |trans-    |trans-    |trans-   |
|             |            |action    |action    |action    |action   |
|-------------+------------+----------+----------+----------+---------|
|Finnish      |            |          |          |          |         |
|Innovation   |            |          |          |          |         |
|Fund (Sitra) |13,585,350  |10.11 %   |9.41 %    |10.14 %   |9.44 %   |
+---------------------------------------------------------------------+


The registered number of shares in Biotie is 144,320,560 and the
number of voting rights attached to the shares amounts to
143,857,305. After the 14,432,000 new shares issued in the share
issue disclosed by the Company through stock exchange releases on 4
December 2009 and 7 December 2009 shall be registered with the Trade
Register on or about 14 December 2009, the number of shares in the
Company shall be 158,752,560 and the number of votes 158,289,305.

In Turku, 10 December 2009

Biotie Therapies Corp.
Timo Veromaa, President and CEO

For further information, please contact:
Virve Nurmi, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

www.biotie.com

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