Biohit Oyj - Company Announcement

Kazakhstan's GastroPanel Screening Yields Encouraging Results

Biohit Oyj April 19, 2013 at 9:30 A.M. local time (EET)



The GastroPanel screening study started by Biohit Oyj and the Medical Center of
the President's Affairs Administration of the Republic of Kazakhstan in the
autumn of 2012 has been completed. The initial findings are encouraging: The
GastroPanel examination has worked excellently in the pilot project. 

The Kazakhstan pilot project has a large data sample of over 830 patients,
which has been carefully examined and analysed. Based on the results of the
GastroPanel examination, less than 30% of the examined persons had an entirely
normal stomach mucosa. Even more significant was the finding that the stomach
mucosa of more than 17% of the patients was inflicted by advanced-stage
atrophic gastritis.  Because atrophic gastritis is the single most important
risk factor for stomach cancer, these individuals should undergo an urgent
gastroscopy examination due to the high risk of stomach cancer. This is not
necessary, however, for the rest (almost 83%) of the examined individuals,
because for them the GastroPanel examination is sufficient to inform the doctor
that no alarming changes have taken place on the stomach mucosa. 

Biohit Oyj Scientific Advisor, Professor and MD Pentti Sipponen: Stomach cancer
is often diagnosed at a late stage and less than a fifth (≤20%) of these
patients live for longer than 5 years. Therefore, the only way to improve the
survival rate is to diagnose the stomach cancer at an earlier stage. With this
purpose in mind, the GastroPanel examination helps assign further examinations
for the patients with the highest level of risk. 

Scientific Director, Professor and MD Kari Syrjänen, Biohit Oyj: Atrophic
gastritis and Helicobacter pylori infections appear to be common in Kazakhstan.
GastroPanel can be used as an objective health check of the stomach in clinical
work to help decide which patients require a gastroscopy. 

Managing Director Semi Korpela, Biohit Oyj: A correct diagnosis is a
prerequisite for the provision of the correct treatment. The GastroPanel
examination is a targeted diagnostics method, which spares both the patient and
care resources. The pilot implemented in Kazakhstan provides encouragement for
making GastroPanel examinations a more common part of basic healthcare. 



Additional information:

CEO Semi Korpela, Biohit Oyj
Tel. +358 9 773 861
semi.korpela@biohit.fi
www.biohit.fi



Biohit in Brief

Biohit Oyj is a Finnish biotechnology company operating globally that was
established in 1988. Biohit's mission is "Innovating for Health". The purpose
of the company is to take social responsibility and produce innovation, new
technologies and analysis systems for use in medicine, research institutions
and industry, helping to promote research and diagnostics and to improve the
quality of life of people by means of preventing disease, human suffering and
financial loss. We are committed to social responsibility and it is our duty to
spread knowledge about the Group 1 human carcinogen, acetaldehyde, and innovate
and develop the marketing and availability of our products and services. Biohit
is headquartered in Helsinki and its subsidiaries are located in China and the
United Kingdom. Since 1999, Biohit's Series B shares (BIOBV) have been listed
in the NASDAQ OMX Helsinki Oy Small cap/Healthcare sector. 



Additional information about the GastroPanel examination:

Biohit Oyj has developed the GastroPanel biomarker tests, a unique blood sample
examination for the screening and diagnosis of Helicobacter pylori infection
and damage or dysfunction of the mucous membrane (atrophic gastritis) of the
stomach. Unlike the H. pylori examinations still being used (13C urea breath
test and stool antigen test), the GastroPanel tests reliably detect the H.
pylori infection, the typically asymptomatic condition atrophic gastritis, and
associated risks, including cancer. 

The April 2012 Maastricht IV consensus report of the European Helicobacter
Pylori Study Group recommends blood sample biomarker tests as a reliable method
of diagnosis of diseases of the stomach mucosa and associated risk conditions.
Researchers recommend biomarker tests for the diagnosis and follow-up of
Helicobacter pylori infection and especially for atrophic gastritis that causes
achlorhydric stomachs, as well as to the screening of asymptomatic patients.
The report emphasises the fact that H. Pylori eradication therapy does not cure
precancerous gastric conditions. This is why gastroscopy and biopsy
examinations are recommended at regular intervals of 2-3 years for patients
with moderately severe or severe atrophic gastritis. Without gastroscopy and
biopsy examination, atrophic gastritis in the entire stomach (precancerous
condition) and its location can only be diagnosed with a GastroPanel biomarker
test. 

The international Healthy Stomach Initiative group's 16 gastroenterology
experts from 12 countries came to the same conclusions. Biomarker tests can be
used to diagnose and screen atrophic gastritis and related risks in both
asymptomatic patients and patients with abdominal discomfort
(www.biohithealthcare.com: Investors/ Stock Exchange Releases: 17/02/2012
Biohit Oyj's GastroPanel biomarker test recommended). According to the
taskforce, GastroPanel biomarker tests, unlike the Helicobacter pylori
examination tests still in use, reliably diagnose the most significant risk
conditions of the acid-free stomach (atrophic gastritis). With the help of the
GastroPanel test, patients can be referred to appropriate further examinations,
therapy and treatment. At the same time it is also possible to reliably
diagnose patients who have a “healthy” stomach, i.e. patients who do not have
H. pylori infection and/or atrophic gastritis. 

 An IARC (WHO agency on cancer research) classification of October 2009 states
that acetaldehyde in alcoholic beverages and naturally generated in alcohol is
a group 1 carcinogen and is therefore as carcinogenic as H. pylori, asbestos,
formaldehyde and benzene. GastroPanel biomarker tests reliably detect an
anacidic stomach which is the major risk factor of gastric cancer. In addition,
recent studies show that acetaldehyde generated in an anacidic stomach is a
significant reason for gastric and oesophageal cancer risk associated with the
condition. Microbes from the mouth can colonise an acid-free stomach and
produce carcinogenic acetaldehyde from sugar and alcohol. According to gene
studies this is one of the major risk factors of gastric and oesophageal
cancer. The risk can be reduced with the help of another Finnish innovation -
prescription-free Acetium capsules, which are taken during food and alcohol
consumption, to bind (neutralise) carcinogenic acetaldehyde in the stomach. 



Literature:

1. Malfertheiner P et al. Management of Helicobacter pylori infection--the
Maastricht IV/ Florence Consensus Report. http://gut.bmj.com on May 18, 2012.
European H. pylori Study Group, ESPSG. 
2. Agréus L et al. Rationale in diagnosis and screening of atrophic gastritis
with stomach-specific plasma biomarkers. Scand J Gastroenterol 2012;47:136-47. 
3. World Health Organisation WHO, 2009.
www.iarc.fr/en/media-centre/pr/2009/pdfs/pr196_E.pdf.