Biotie Therapies - Major shareholder announcements

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       April 12, 2016
at 4.20 p.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the
"Company") has on April 11, 2016 received a notification in accordance with
Chapter 9, Section 5 of the Finnish Securities Markets Act from Vivo Capital
VIII, LLC on behalf of itself and Vivo Capital Fund VIII, L.P.

According to the notification, the total number of Biotie shares owned directly
or through financial instruments by Vivo Capital VIII, LLC and its funds has
fallen below the threshold of 5 per cent on 11 April, 2016. Biotie's registered
total number of shares and voting rights amounting to 1,089,608,083 has been
used in the calculation of percentages for the announcement.

Total positions of Vivo Capital VIII, LLC and its funds subject to the
notification:

+-----------------------+----------------+---------------------+---------------+
|                       |% of shares and |% of shares and      |Total of both  |
|                       |voting rights   |voting rights through|in % (A+B)     |
|                       |(total of A)    |financial instruments|               |
|                       |                |(total of B)         |               |
+-----------------------+----------------+---------------------+---------------+
|Resulting situation on |Below 5 %       |Below 5 %            |Below 5 %      |
|the date on which      |                |                     |               |
|threshold was crossed  |                |                     |               |
|or reached             |                |                     |               |
+-----------------------+----------------+---------------------+---------------+
|Position of previous   |8.98            |4.78                 |13.76          |
|notification (if       |                |                     |               |
|applicable)            |                |                     |               |
+-----------------------+----------------+---------------------+---------------+

Notified details of the resulting situation on the date on which the threshold
was crossed or reached:

A: Shares and voting rights

+-----------------------+---------------------------+--------------------------+
|Class/type of shares   |Number of shares and voting|% of shares and voting    |
|ISIN code (if possible)|rights                     |rights                    |
|                       +---------+-----------------+---------+----------------+
|                       |Direct   |Indirect         |Direct   |Indirect        |
|                       |(SMA 9:5)|(SMA 9:6 and 9:7)|(SMA 9:5)|(SMA 9:6 and    |
|                       |         |                 |         |9:7)            |
+-----------------------+---------+-----------------+---------+----------------+
|Shares                 |-        |-                |-        |-               |
|(FI0009011571)         |         |                 |         |                |
+-----------------------+---------+-----------------+---------+----------------+
|American Depositary    |-        |-                |-        |-               |
|Shares (ADS), each     |         |                 |         |                |
|representing 80 Shares |         |                 |         |                |
|(FI0009011571)         |         |                 |         |                |
+-----------------------+---------+-----------------+---------+----------------+
|                       |         |                 |         |                |
+-----------------------+---------+-----------------+---------+----------------+
|SUBTOTAL A             |                           |Below 5 %                 |
+-----------------------+---------------------------+--------------------------+

B: Financial instruments according to SMA 9:6a

+-----------------+-------------+-------------+-------------+---------+--------+
|Type of financial|Expiration   |Exercise/    |Physical or  |Number of|% of    |
|instrument       |date         |Conversion   |cash         |shares   |shares  |
|                 |             |period       |settlement   |and      |and     |
|                 |             |             |             |voting   |voting  |
|                 |             |             |             |rights   |rights  |
+-----------------+-------------+-------------+-------------+---------+--------+
|Warrants         |Nov 1, 2020  |Nov 1, 2015 -|Physical     |-        |-       |
|entitling to     |             |Nov 1, 2020  |settlement   |         |        |
|subscribe for    |             |             |             |         |        |
|Shares           |             |             |             |         |        |
|(FI0009011571)   |             |             |             |         |        |
+-----------------+-------------+-------------+-------------+---------+--------+
|                 |             |             |             |         |        |
+-----------------+-------------+-------------+-------------+---------+--------+
                                              |SUBTOTAL B   |         |Below 5 |
                                              |             |         |%       |
                                              +-------------+---------+--------+

Full chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held starting with the ultimate
controlling natural person or legal entity:

+--------------------+-------------------+-----------------------+-------------+
|Name                |% of shares and    |% of shares and voting |Total of both|
|                    |voting rights      |rights through         |             |
|                    |                   |financial instruments  |             |
+--------------------+-------------------+-----------------------+-------------+
|Vivo Capital VIII,  |Below 5 %          |Below 5 %              |Below 5 %    |
|LLC                 |                   |                       |             |
+--------------------+-------------------+-----------------------+-------------+
|Vivo Capital Fund   |Below 5 %          |Below 5 %              |Below 5 %    |
|VIII, L.P.          |                   |                       |             |
+--------------------+-------------------+-----------------------+-------------+
|Vivo Capital Surplus|Below 5 %          |Below 5 %              |Below 5 %    |
|Fund VIII, L.P.     |                   |                       |             |
+--------------------+-------------------+-----------------------+-------------+

According to the notification, Vivo Capital VIII, LLC is the general partner of
(i) Vivo Capital Fund VIII, L.P. and (ii) Vivo Capital Surplus Fund VIII, L.P.
Further according to the notification, neither Vivo Capital VIII, LLC nor any
other entity under its control holds shares or financial instruments in the
Company exceeding a notification threshold.



In Turku, April 12, 2016

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Investor Relations Manager, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

DISTRIBUTION:

Nasdaq Helsinki Ltd
Main Media
www.biotie.com








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