Biotie Therapies - Major shareholder announcements

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       12 April, 2016
at 11.20 p.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the
"Company") has on April 12, 2016 received a notification in accordance with
Chapter 9, Section 5 of the Finnish Securities Markets Act ("SMA") from Mr.
Samuel D. Isaly on behalf of himself and OrbiMed Advisors LLC, OrbiMed Capital
GP V LLC and OrbiMed Private Investments V, LP.

According to the notification, the total number of Biotie shares owned directly
or through financial instruments by Samuel D. Isaly and entities under his
control has fallen below the threshold of 5 per cent on April 11, 2016. Biotie's
registered total number of shares and voting rights amounting to 1,089,608,083
has been used in the calculation of percentages for the announcement.

Total positions of Samuel D. Isaly and entities under his control subject to the
notification:

+-----------------------+----------------+---------------------+---------------+
|                       |% of shares and |% of shares and      |Total of both  |
|                       |voting rights   |voting rights through|in % (A + B)   |
|                       |(total of A)    |financial instruments|               |
|                       |                |(total of B)         |               |
+-----------------------+----------------+---------------------+---------------+
|Resulting situation on |Below 5 %       |Below 5 %            |Below 5 %      |
|the date on which      |                |                     |               |
|threshold was crossed  |                |                     |               |
|or reached             |                |                     |               |
+-----------------------+----------------+---------------------+---------------+
|Position of previous   |6.76            |4.78                 |11.54          |
|notification (if       |                |                     |               |
|applicable)            |                |                     |               |
+-----------------------+----------------+---------------------+---------------+

Notified details of the resulting situation on the date on which the threshold
was crossed or reached:

A: Shares and voting rights

+-----------------------+---------------------------+--------------------------+
|Class/type of shares   |Number of shares and voting|% of shares and voting    |
|ISIN code (if possible)|rights                     |rights                    |
|                       +---------+-----------------+---------+----------------+
|                       |Direct   |Indirect         |Direct   |Indirect        |
|                       |(SMA 9:5)|(SMA 9:6 and 9:7)|(SMA 9:5)|(SMA 9:6 and    |
|                       |         |                 |         |9:7)            |
+-----------------------+---------+-----------------+---------+----------------+
|Shares                 |-        |-                |-        |-               |
|(FI0009011571)         |         |                 |         |                |
+-----------------------+---------+-----------------+---------+----------------+
|American Depositary    |-        |-                |-        |-               |
|Shares (ADS), each     |         |                 |         |                |
|representing 80 Shares |         |                 |         |                |
|(FI0009011571)         |         |                 |         |                |
+-----------------------+---------+-----------------+---------+----------------+
|SUBTOTAL A             |                           |Below 5 %                 |
+-----------------------+---------------------------+--------------------------+

B: Financial instruments according to SMA 9:6a

+-----------------+-------------+-------------+-------------+---------+--------+
|Type of financial|Expiration   |Exercise/    |Physical or  |Number of|% of    |
|instrument       |date         |Conversion   |cash         |shares   |shares  |
|                 |             |period       |settlement   |and      |and     |
|                 |             |             |             |voting   |voting  |
|                 |             |             |             |rights   |rights  |
+-----------------+-------------+-------------+-------------+---------+--------+
|Warrants         |Nov 1, 2020  |Nov 1, 2015 -|Physical     |-        |-       |
|entitling to     |             |Nov 1, 2020  |settlement   |         |        |
|subscribe for    |             |             |             |         |        |
|Shares           |             |             |             |         |        |
|(FI0009011571)   |             |             |             |         |        |
+-----------------+-------------+-------------+-------------+---------+--------+
                                              |SUBTOTAL B   |         |Below 5 |
                                              |             |         |%       |
                                              +-------------+---------+--------+

Full chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held starting with the ultimate
controlling natural person or legal entity:

+-----------------------+-----------------+----------------------+-------------+
|Name                   |% of shares and  |% of shares and voting|Total of both|
|                       |voting rights    |rights through        |             |
|                       |                 |financial instruments |             |
+-----------------------+-----------------+----------------------+-------------+
|Samuel D. Isaly        |Below 5 %        |Below 5 %             |Below 5 %    |
+-----------------------+-----------------+----------------------+-------------+
|OrbiMed Advisors LLC   |Below 5 %        |Below 5 %             |Below 5 %    |
+-----------------------+-----------------+----------------------+-------------+
|OrbiMed Capital GP V   |Below 5 %        |Below 5 %             |Below 5 %    |
|LLC                    |                 |                      |             |
+-----------------------+-----------------+----------------------+-------------+
|OrbiMed Private        |Below 5 %        |Below 5 %             |Below 5 %    |
|Investments V, LP      |                 |                      |             |
+-----------------------+-----------------+----------------------+-------------+

According to the notification, Samuel D. Isaly is the managing member of and
owner of a controlling interest in OrbiMed Advisors LLC, which is the sole
managing member of OrbiMed Capital GP V LLC. OrbiMed Capital GP V LLC is the
general partner of OrbiMed Private Investments V, LP. Further, according to the
notification neither Samuel D. Isaly nor any other entity under his control
holds shares or financial instruments in the Company exceeding a notification
threshold.

In Turku, April 12, 2016

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Investor Relations Manager, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

DISTRIBUTION:

Nasdaq Helsinki Ltd
Main Media
www.biotie.com








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