Biotie Therapies - Major shareholder announcements

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       December
16, 2015 at 8.00 a.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the
"Company") has on December 15, 2015 received a notification in accordance with
Chapter 9, Section 5 of the Finnish Securities Markets Act from Mr. Samuel D.
Isaly on behalf of himself and OrbiMed Advisors LLC, OrbiMed Capital GP V LLC
and OrbiMed Private Investments V, LP as a result of the implementation of
changes to the transparency directive in the Finnish Securities Market Act.

According to the notification, the total number of Biotie shares owned directly
or through financial instruments by Samuel D. Isaly and entities under his
control was 11.54 per cent of Biotie's total number of shares and voting rights
on November 26,s 2015. Biotie's registered total number of shares and voting
rights amounting to 1,086,940,271 has been used in the calculation of
percentages for the announcement.

Total positions of Samuel D. Isaly and entities under his control subject to the
notification:

+-----------------------+----------------+---------------------+---------------+
|                       |% of shares and |% of shares and      |Total of both  |
|                       |voting rights   |voting rights through|in % (A + B)   |
|                       |(total of A)    |financial instruments|               |
|                       |                |(total of B)         |               |
+-----------------------+----------------+---------------------+---------------+
|Resulting situation on |6.76            |4.78                 |11.54          |
|the date on which      |                |                     |               |
|threshold was crossed  |                |                     |               |
|or reached             |                |                     |               |
+-----------------------+----------------+---------------------+---------------+
|Position of previous   |7.49            |N/A                  |N/A            |
|notification (if       |                |                     |               |
|applicable)            |                |                     |               |
+-----------------------+----------------+---------------------+---------------+

Notified details of the resulting situation on the date on which the threshold
was crossed or reached:

A: Shares and voting rights

+----------------------+----------------------------+--------------------------+
|Class/type of shares  |Number of shares and voting |% of shares and voting    |
|ISIN code (if         |rights                      |rights                    |
|possible)             +---------+------------------+---------+----------------+
|                      |Direct   |Indirect          |Direct   |Indirect        |
|                      |(SMA 9:5)|(SMA 9:6 and 9:7) |(SMA 9:5)|(SMA 9:6 and    |
|                      |         |                  |         |9:7)            |
+----------------------+---------+------------------+---------+----------------+
|Shares                |-        |51,944,444        |-        |4.78            |
|(FI0009011571)        |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|Shares                |-        |21,493,760        |-        |1.98            |
|(FI0009011571)        |         |                  |         |                |
|represented by        |         |                  |         |                |
|268,672 ADSs          |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|                      |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|SUBTOTAL A            |73,438,204                  |6.76                      |
+----------------------+----------------------------+--------------------------+

For further information on the ADSs representing the Company's shares, the
notification refers to the stock exchange release issued by the Company on June
11, 2015.

B: Financial instruments according to SMA 9:6a

+-----------------+------------+------------+------------+------------+--------+
|Type of financial|Expiration  |Exercise/   |Physical or |Number of   |% of    |
|instrument       |date        |Conversion  |cash        |shares and  |shares  |
|                 |            |period      |settlement  |voting      |and     |
|                 |            |            |            |rights      |voting  |
|                 |            |            |            |            |rights  |
+-----------------+------------+------------+------------+------------+--------+
|Warrants         |Nov 1, 2020 |Nov 1, 2015 |Physical    |51,944,444  |4.78    |
|entitling to     |            |- Nov       |settlement  |            |        |
|shares (new or   |            |1, 2020     |            |            |        |
|treasury shares) |            |            |            |            |        |
|(FI0009011571)   |            |            |            |            |        |
+-----------------+------------+------------+------------+------------+--------+
|                 |            |            |            |            |        |
+-----------------+------------+------------+------------+------------+--------+
                                            |SUBTOTAL B  |51,944,444  |4.78    |
                                            +------------+------------+--------+

For further information on the warrants, the notification refers to the stock
exchange release issued by the Company on April 23, 2015.

Full chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held starting with the ultimate
controlling natural person or legal entity:

+-----------------------+-----------------+----------------------+-------------+
|Name                   |% of shares and  |% of shares and voting|Total of both|
|                       |voting rights    |rights through        |             |
|                       |                 |financial instruments |             |
+-----------------------+-----------------+----------------------+-------------+
|Samuel D. Isaly        |0                |0                     |0            |
+-----------------------+-----------------+----------------------+-------------+
|OrbiMed Advisors LLC   |0                |0                     |0            |
+-----------------------+-----------------+----------------------+-------------+
|OrbiMed Capital GP V   |0                |0                     |0            |
|LLC                    |                 |                      |             |
+-----------------------+-----------------+----------------------+-------------+
|OrbiMed Private        |6.76             |4.78                  |11.54        |
|Investments V, LP      |                 |                      |             |
+-----------------------+-----------------+----------------------+-------------+

According to the notification, Samuel D. Isaly is the managing member of and
owner of a controlling interest in OrbiMed Advisors LLC, which is the sole
managing member of OrbiMed Capital GP V LLC. OrbiMed Capital GP V LLC is the
general partner of OrbiMed Private Investments V, LP. Further, according to the
notification neither Samuel D. Isaly nor any other entity under his control,
other than OrbiMed Private Investments V, LP, holds any shares or financial
instruments in the Company.

In Turku, December 16, 2015

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Investor Relations Manager, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

DISTRIBUTION:

NASDAQ OMX Helsinki Ltd
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www.biotie.com






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