Biotie Therapies - Major shareholder announcements

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

BIOTIE THERAPIES CORP.             STOCK EXCHANGE RELEASE       December
14, 2015 at 3.05 p.m.

Disclosure under Chapter 9, Section 5 of the Finnish Securities Markets Act

Biotie Therapies Corp. (Nasdaq Helsinki BTH1V; NASDAQ: BITI) ("Biotie" or the
"Company") has on December 12, 2015 received a notification in accordance with
Chapter 9, Section 5 of the Finnish Securities Markets Act from Versant Ventures
III, LLC on behalf of itself and Versant Venture Capital III, L.P. as a result
of the implementation of changes to the transparency directive in the Finnish
Securities Market Act.

According to the notification, the total number of Biotie shares owned directly
or through financial instruments by Versant Ventures III, LLC and its funds was
8.02 per cent of Biotie's total number of shares and voting rights on 26
November 2015. Biotie's registered total number of shares and voting rights
amounting to 1,086,940,271 has been used in the calculation of percentages for
the announcement.

Total positions of Versant Ventures III, LLC and its funds subject to the
notification:

+-----------------------+----------------+---------------------+---------------+
|                       |% of shares and |% of shares and      |Total of both  |
|                       |voting rights   |voting rights through|in % (A + B)   |
|                       |(total of A)    |financial instruments|               |
|                       |                |(total of B)         |               |
+-----------------------+----------------+---------------------+---------------+
|Resulting situation on |5.59            |2.43                 |8.02           |
|the date on which      |                |                     |               |
|threshold was crossed  |                |                     |               |
|or reached             |                |                     |               |
+-----------------------+----------------+---------------------+---------------+
|Position of previous   |8.84            |N/A                  |N/A            |
|notification (if       |                |                     |               |
|applicable)            |                |                     |               |
+-----------------------+----------------+---------------------+---------------+


Notified details of the resulting situation on the date on which the threshold
was crossed or reached:

A: Shares and voting rights

+----------------------+----------------------------+--------------------------+
|Class/type of shares  |Number of shares and voting |% of shares and voting    |
|ISIN code (if         |rights                      |rights                    |
|possible)             +---------+------------------+---------+----------------+
|                      |Direct   |Indirect          |Direct   |Indirect        |
|                      |(SMA 9:5)|(SMA 9:6 and 9:7) |(SMA 9:5)|(SMA 9:6 and    |
|                      |         |                  |         |9:7)            |
+----------------------+---------+------------------+---------+----------------+
|Shares                |-        |60,716,690        |-        |5.59            |
|(FI0009011571)        |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|                      |         |                  |         |                |
+----------------------+---------+------------------+---------+----------------+
|SUBTOTAL A            |60,716,690                  |5.59                      |
+----------------------+----------------------------+--------------------------+


B: Financial instruments according to SMA 9:6a

+-----------------+------------+------------+------------+------------+--------+
|Type of financial|Expiration  |Exercise/   |Physical or |Number of   |% of    |
|instrument       |date        |Conversion  |cash        |shares and  |shares  |
|                 |            |period      |settlement  |voting      |and     |
|                 |            |            |            |rights      |voting  |
|                 |            |            |            |            |rights  |
+-----------------+------------+------------+------------+------------+--------+
|Warrants         |Nov 1, 2020 |Nov 1, 2015 |Physical    |26,448,349  |2.43    |
|entitling to     |            |- Nov       |settlement  |            |        |
|shares (new or   |            |1, 2020     |            |            |        |
|treasury shares) |            |            |            |            |        |
|(FI0009011571)   |            |            |            |            |        |
+-----------------+------------+------------+------------+------------+--------+
|                 |            |            |            |            |        |
+-----------------+------------+------------+------------+------------+--------+
                                            |SUBTOTAL B  |26,448,349  |2.43    |
                                            +------------+------------+--------+


For further information on the warrants, the notification refers to the stock
exchange release issued by the Company on April 23, 2015.

Full chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held starting with the ultimate
controlling natural person or legal entity:

+---------------------+------------------+-----------------------+-------------+
|Name                 |% of shares and   |% of shares and voting |Total of both|
|                     |voting rights     |rights through         |             |
|                     |                  |financial instruments  |             |
+---------------------+------------------+-----------------------+-------------+
|Versant Ventures III,|0                 |0                      |0            |
|LLC                  |                  |                       |             |
+---------------------+------------------+-----------------------+-------------+
|Versant Venture      |5.55              |2.42                   |7.97         |
|Capital III, L.P.    |                  |                       |             |
+---------------------+------------------+-----------------------+-------------+
|Versant Side Fund    |0.03              |0.01                   |0.05         |
|III, L.P.            |                  |                       |             |
+---------------------+------------------+-----------------------+-------------+


According to the notification, Versant Ventures III, LLC is the sole general
partner of (i) Versant Venture Capital III, L.P. and (ii) Versant Side Fund III,
L.P. Neither Versant Ventures III, LLC nor any other entity under its control,
other than (i) Versant Venture Capital III, L.P. and (ii) Versant Side Fund III,
L.P., holds any shares or financial instruments in the Company.



In Turku, December 14, 2015

Biotie Therapies Corp.

Timo Veromaa
President and CEO

For further information, please contact:

Virve Nurmi, Investor Relations Manager, Biotie Therapies Corp.
tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com

DISTRIBUTION:

NASDAQ OMX Helsinki Ltd
Main Media
www.biotie.com






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